If a man is suffering from jaundice and you give him a piece of sugar candy, he will say that it is very bitter. But is sugar candy bitter? No, it is very sweet. And the medicine for jaundice is that sugar. Modern science prescribes this, and it is prescribed in the Vedic literature also. So if we take a great quantity of this sugar candy, then we will be relieved from jaundice. And when there is relief, then one says, “Oh, this is very sweet.” So the modern jaundice of a godless civilization can be cured by this chanting of Hare Krishna. In the beginning it may appear bitter, but when one advances, then he will see how pleasing it is.
We are so full of miseries because we have identified ourselves with the material world. Therefore we are unhappy. Anxieties and fearfulness are due to our misidentifying with the material world. As soon as one understands his identity, his relationship with God, then immediately he becomes happy.
Ref: Chapter 8a, Science of Self Realization authored by Srila Prabhupada (Founder – Acharya, ISKCON)